Case of Myxoedema Developing during p-Aminosalicylic Acid Therapy

Mechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.

The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...

Failure of P-(di-n-propylsulfamyl)-benzoic acid (benemid) to influence p-aminosalicylic acid blood levels.

Para-Aminosalicylic Acid: Pas

aminosalicylic acid to 5-aminosalicylic acid in topical treatment of ulcerative colitis. Digestion

Effective treatment of manganese-induced occupational Parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.

OBJECTIVE Chronic manganese (Mn) intoxication induces syndromes resembling Parkinson disease. The clinical intervention has largely been unsuccessful. We report a 17-year follow-up study of effective treatment of occupational Mn parkinsonism with sodium para-aminosalicylic acid (PAS). METHODS The patient, female and aged 50 at the time of treatment, was exposed to airborne Mn for 21 years (19...